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Treatment Symptomatic palliative therapies may be beneficial and include high-protein diets with egg white (approximately 2 to 4 egg whites/day for a 25-kg dog), zinc (2 mg/kg q24h PO) niacinamide (250 to 500 mg/dog q24h PO), ursodeoxycholic acid (10 to 15 mg/kg/day PO), vitamin E (10 IU/kg daily PO), SAMe (20 mg/kg/day PO 2 hours before feeding), and fatty acid supplementation

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Moreover, -Escin not only shows dose-dependent viral load inhibition in SARS-CoV-2 and canine coronavirus infection models but also inhibits the NF-B/IL-6/TNF- signaling axis in macrophages, significantly reducing the levels of inflammatory factors, demonstrating broad-spectrum antiviral and immunomodulatory activities (Pearanda Figueredo et al., 2024)

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