Both L-glutamate and L-aspartate are dietary non-essential AAs, which can be synthesized readily in the brain, so they show much lower rates of uptake into the brain at the BBB (Smith, 2000)
Having a way to measure brain ageing with a home test kit from a pin prick of blood, means we can realistically see what the impact of specific diet changes and antioxidant supplements might be
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Such a pathway would be needed, however, if the surface-exposed TNR molecules suffer modifications to their sugar moieties, and therefore require re-glycosylation, and/or a specific glycosylation pattern is needed to recycle perisynaptic TNR
International Journal of Molecular Sciences 23, 16151