nitric oxide cycle glutathione produced by a nitric oxide synthase reacts with GLUTATHIONE SYNTHESIS - PMC

Cuadrado and colleagues first showed that GSK-3 inhibits NRF2 activity, but the identification of sites in NRF2 that are phosphorylated by GSK-3 was achieved several years later using two-dimensional electrophoresis and mass spectrometry: GSK-3 phosphorylates a group of Ser residues at the level of DSGIS motif in the Neh6 domain of NRF2, and this event represents the signal for the recognition by the adapter protein -TrCP, that targets NRF2 for ubiquitination and proteasomal degradation in a KEAP1-independent manner [150, 151]

Ongoing studies are exploring the potential of glutathione in treating various health conditions, from neurodegenerative diseases to autoimmune disorders

Data availability The RNA-seq data generated in this study has been deposited in the Gene Expression Omnibus (GEO) database at NCBI under accession code GSE249592

Hoang T, Kuljanin M, Smith MD, Jelokhani-Niaraki M

Proteomics 3, 715728