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Sorafenib Combination therapies targeting complementary molecular pathways represent a promising strategy to overcome resistance while potentiating therapeutic efficacy [118]

In conclusion, targeting the gut microbiota is a novel therapeutic direction to improve CKD outcomes, and interventions such as probiotics to modulate the gut microbiota may provide new insights into individualized CKD treatment

This research involved safety risk to researchers handling SARS-CoV-2 infected samples, but all procedures were approved by IRB and IACUC protocols, and the study was performed in biosafety cabinets to ensure no exposure to active viruses

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