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mutS and mutL alleles contribute to reducing the genetic barrier to recombination (Davidsen and Tnjum, 2006), as it is known that MutS and MutL mismatch binding activity edit (prevent) homologous and homoeologous recombination, limiting the stability of heteroduplex intermediates, with the contribution of the RecBCD nuclease (tambuk and Radman, 1998)

Senescence in tumours: evidence from mice and humans

The Broad Institute Connectivity Map analyzed 1,309 bioactive molecules and selected GHK-Cu as the single best agent for reversing metastatic colon cancer gene signatures