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Warburg's discovery was recognized and confirmed in various human tumors with radioactive glucose analogs using (fluorodeoxyglucose) to examine glucose utilization in normal and tumor tissues (30)

mTOR inhibition using a bitopic inhibitor effectively reduced CSC populations, suppressed anchorage-independent growth, and diminished chemoresistance, highlighting mTORs critical role in maintaining stemness and drug resistance in breast cancer cells [33]

A glucose-6-phosphate dehydrogenase (G6PD) screening test is mandatory before administering high-dose IVC, as deficient patients face a risk of hemolytic anemia

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