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In the upper small intestine where the pH changes to less acidic conditions, haptocorrin is degraded by pancreatic proteases, releasing B12 which subsequently becomes bound to gastric intrinsic factor (IF) to form the IFB12 complex

Deep structural changes, significant volume loss, and profound sun damage may need other interventions

In this case, we do not experience anemia (or we may have very mild or temporary symptoms in some cases), but this does not mean that B12 levels are still low, and we will not avoid clinical symptoms later on (with uncertain onset, in the short term or in the medium/long term)

PMID: 13601774

Jul 2020;267(7):1896-1905