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LOX inhibitors inhibit LOX primarily by trapping free radicals (Shah et al., 2018a), which in turn inhibits lipid peroxidation

These results support the hypothesis that the T2-induced 15LO1 pathwayinduced alteration of intracellular redox balance enhances T2 inflammatory responses ex vivo

18d), the strong binding between O 2 and pFeSAN can effectively activate oxygen, being a decisive significance for its subsequently enhanced oxidase-like activity 37,39

doi: 10.1016/j.biopha.2024.116697 151 LiuYXuTMaZZhangCXuMLiQet al

Concurrently, NF-B-driven inflammatory signaling was inhibited by TNF- expression regulation, which reduced cytokine-mediated oxidative stress and hepatocellular damage