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Metaxins are part of the mitochondrial translocation system of the mitochondrial outer membrane, being anchored through their C-terminal region whereas the rest of the protein is oriented to the cytosol (Lister et al., 2007)

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The Fic-domain containing proteins from several pathogenic bacteria catalyze AMPylation of the eukaryotic Rho GTPases to manipulate host cell signaling during infection 5,6,7