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J Nutr 133:3927S3931S Price MC (2002) Longevity Report 91: the role of enzymic cofactors in aging

However, the current understanding of nephron segmental metabolism is mainly based on studies that measured specific substrate utilization, ATP production, and abundance or activities of a small number of metabolic enzymes in nephron segments isolated from rats, mice, and other animal models 17,18,19,23

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Mendhe S, Badge A, Ugemuge S, Chandi D

APAO generates ACR through the formation of 3-acetamidopropanal (3-AAP), which together with H 2 O 2 , results from its metabolism of N1-acetylspermine or N1-acetylspermidine to spermidine or putrescine