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This means that more methylfolate is diverted towards thymidine production, and less is available for methylation reactions.31 In particular, low methylfolate levels are associated with low glutathione.32 Glutathione is important for reducing oxidative stress and helping to halt the self-perpetuating peroxynitrite cycle

Unlike other amino acids, aspartate is not involved in catabolism but rather serves as an amino acid exchange factor for retrograde transport to absorb essential amino acids and balance intracellular or extracellular levels of other amino acids including glycine, histidine, serine, and threonine (67)