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Indomethacin, a potent inhibitor of 3a-hydroxysteroid dehydrogenase, a key enzyme responsible for the synthesis of allopregnanolone (ALLO) and tetradehydrodeoxycorticosterone (THDOC) (potent selective positive allosteric modulators of the GABA A receptors), has been shown to attenuate brain production of ALLO and THDOC and to improve activity in animals with CLF and mild HE [101]

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DILI is a complex condition and is influenced by multiple risk factors, especially idiosyncratic DILI

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