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Consequently, this results in a further build-up of senescent cells in the skin, causing the aging of the skin ( Fibroblasts Skin fibroblasts aging is thought to be key factors of pathological skin aging ( in vitro experiments, it was observed that the ECM derived from papillary fibroblasts provided better support for the longevity of the epidermis compared to ECM from reticular fibroblasts ( in vitro , they transformed into reticular fibroblasts, indicating that an imbalance in the subtypes of fibroblasts may contribute to the aging of the skin ( The normal dermal fibroblasts were categorized into two groups: papillary fibroblasts and reticular fibroblasts, the common markers are COL1A1, COL1A2 et al

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doi: 10.3389/fped.2023.1212405 Received 26 April 2023 Accepted 03 July 2023 Published 27 July 2023 Volume 11 - 2023 Edited by Massimo Zeviani, University of Padua, Italy Reviewed by Carlo Fiore Viscomi, University of Padua, Italy Muhammad Ikram Ullah, Jouf University, Saudi Arabia Updates Copyright 2023 Wu, Jiao, Xia, Yan, Liu, Cao and Ma

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