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Indeed, it has been shown that nAbs to the V3-glycan site of Env bind to residues that associate with the host cell co-receptor CCR5 and neutralization may thus result from inhibition of CCR5 binding rather than inhibition of CD4 binding 23

These could include inadequate quality control in herbal products, as well as low repeatability of bioactivity, bioavailability, and biotransformation of active compounds

In previously immunized animals, IgG on the surface of APC can specifically bind extracellular antigen and mediate uptake of the bound antigen into an intracellular endosomal compartment