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Vitamin C: is supplementation necessary for optimal health

DKD: Diabetic kidney disease AKI: Acute kidney injury ROS: Reactive oxygen species TFR1: Transferrin receptor 1 FTH1: Ferritin heavy chain LOXs: Lipoxygenases NCOA4: Nuclear receptor coactivator 4 RTECs: Renal tubular epithelial cells AA: Arachidonic acid PUFAs: Polyunsaturated fatty acids ACSL4: Acyl-CoA synthetase long chain family member 4 NADPH: Nicotinamide adenine dinucleotide phosphate System Xc - : Cystine/glutamate antiporter system GSH: Glutathione GPX4: Glutathione peroxidase 4 FSP1: Ferroptosis suppressor protein 1 Nrf2: Nuclear factor erythroid 2-related factor 2 AMPK: AMP-activated protein kinase ALOX: Arachidonate lipoxygenase TGF-1: Transforming growth factor beta 1 NF-B: Nuclear factor-B VDACs: Voltage-dependent anion channel 2/3 HO-1: Heme oxygenase-1 HMGB1: High mobility group 1 FPN: Ferroportin IRI: ischemia-reperfusion injury N.A.: Not applicable This study was financially supported by the National Natural Science Foundation of China Joint Project (No

In addition, our results indicate a close correlation between dermoscopic patterns and underlying histologic features

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These findings indicate that hyperglycemia and hyperlipidemia disrupt cardiac antioxidant balance and trigger oxidative stress, which can be reversed by exogenous H 2 S