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Altogether, it is possible that reduced GM-CSF and IFN- could lead to reduced maternal pDC activity, which is important to differentiate T cells in a Th17 phenotype after TLR activation (80), indicating a slightly reduced inflammatory potential in the neonates

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Cytochrome P-450 enzymes mediate the hydroxylation of estradiol and estrone, which is the major Phase I metabolic pathway for endogenous estrogens

This redox stress-sensing adaptive response system has been extensively studied in terms of molecular mechanism and biological significance 61