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This persistent downregulation of Irs2 is especially intriguing, as it may reflect a broader impairment of downstream insulin/IGF-1 signaling, potentially indicating alcohol-induced desensitization to insulin or IGF-1 at the cellular level

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This protocol is designed as a "peptide burst" a short, potent intervention that minimizes the risk of receptor downregulation and insulin resistance while maximizing anabolic response