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Melanotan 1 (afamelanotide) is a linear peptide analogue with selective affinity for MC1R, while Melanotan 2 is a cyclic lactam analogue with broader affinity across multiple melanocortin receptor subtypes

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This phenomenon has also been observed in various PD animal models (77, 78)

Generally, glutathione reductase activity is measured using an enzyme-coupled kinetic assay, although some colorimetric methods are also available (Sauberlich, 1984)

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