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A total of 10 volunteers received a dose of 0.5, 1, 2.5, or 5 g resveratrol orally (Boocock et al., 2007)

153,154,155,156,157 S6K1 phosphorylates SRPK2, enabling the nuclear translocation of this kinase, which in turn phosphorylates serine/arginine-rich (SR) splicing factors

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In this flux simulation, we used a recently updated zebrafish genome-scale metabolic model, Zebrafish1, containing the most extensive coverage of its metabolic network with 8,344 metabolites and 12,910 reactions