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Liang Y, Peng C, Su N, Li QY, Chen SW, Wu D, Wu B, Gao Y, Xu ZT, Dan Q, et al

Enzalutamide was developed by ligand-based drug design, which relied on the pharmacophores of known drugs, to bind and inhibit the AR with a much improved binding affinity (IC 50 =21 nmol/L, compared with 160 nmol/L for bicalutamide) 162

This does not affect the integrity of the product

4.2.2.2 Reduced Lactobacillus in OA: iron metabolism regulation and probiotic potential For patients with KOA, the abundance of Lactobacillus significantly decreased (Gaspar et al., 2025)