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Keap1 binds to the Neh2 domain of Nrf2 via its high-affinity ETGE and low-affinity DLG motifs via a hinge and latch mechanism [20]

Therapies and Models of Citrin Deficiency While the dysfunction of citrin manifests in a complex clinical phenotype across different life stages, therapeutic options remain limited, and no current treatment addresses the underlying metabolic dysregulation comprehensively

Confocal images were captured using a 100 oil immersion objective on a Yokogawa/Olympus CV1000 spinning disk confocal microscope

On the other hand, studies report that MK-677 has a considerably longer half-life of 4-6 hours, and daily oral intake can significantly increase GH and IGF-1 levels [5, 7]

Insulinlike growth factor1 lowers spreading depression susceptibility and reduces oxidative stress