glutathione metabolic process an damino acid metabolism amino Major metabolic and biosynthetic fates

Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]

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Glutathione and ALA, Vitamin E Alpha lipoic acid has been suggested as a cofactor for glutathione, probably due to its ability to scavenge free radicals and help regenerate various naturally-occurring antioxidants

Funding This work was supported by Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq), Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Fundao de Amparo Pesquisa do Estado do Rio Grande do Sul (FAPERGS), and National Institute of Science and Technology for Excitotoxicity and Neuroprotection (INCTEN/MCT)

So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest