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They also play important roles in preserving spermatogonial homeostasis and guaranteeing the equilibrium between proliferation and differentiation in the germ cell population [66], miR-224, which targets DMRT1 in mice to encourage SSC self-renewal [66], The commencement of spermatogonial meiosis has been linked to miR-202-3p, whereas miR-10b targets the transcription factor KLF4 in mice to promote spermatogonial SSC self-renewal, which affects the equilibrium between germ cell maintenance and differentiation [67, 68]

177 Transcranial electrical stimulation (tES) is the most widely used method and involves the application of a small direct or alternating current to the scalp via two electrodes

For example, it increases the abundance of Bacteroides and Prevotella while reducing Firmicutes and Actinobacteria [169, 170], essentially reversing the microbial imbalance typically observed in PD [133]

10.1021/acsnano.3c00093 85 HartingM