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10.3233/JPD-240353 151 PatelP.GaralaK.SinghS.PrajapatiB

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Because they stimulate natural growth hormone production rather than replacing it, they carry a lower risk profile than synthetic hormone replacement therapies

For example, co-administration of L-carnitine and -lipoic acid did not improve insulin resistance but markedly ameliorated mitochondrial ultrastructure and reduced serum liver enzyme levels, suggesting a preferential correction of mitochondrial injury ( / Leiden mice, only the combined intervention with nicotinamide riboside, rather than either monotherapy, significantly attenuated obesity and hepatic steatosis, accompanied by coordinated upregulation of genes involved in fatty acid oxidation and insulin signaling (61)