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In other studies, shikonin and its analogues have been reported to have insecticidal activities toward Culex pipiens (Michaelakis, et al., 2009), Tetranychus urticae (Stefania, et al., 2017), and Nilaparvata lugens (Shang et al., 2019)

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Studies have shown that excessive HOCl/OH generation during neutrophil activation induces extensive DNA damage and subsequent DNA repair mechanisms which will result in NETosis [246, 247]

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