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Acetazolamide is the first-line of prophylaxis, FDA approved drug for AMS that works at the level of kidneys and causes bicarbonate diuresis and metabolic acidosis, promoting ventilatory acclimatization to hypoxia 25

Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)

Technol 159:104936 Murtaza B, Li X, Dong L, Saleemi MK, Iqbal M, Majeed S, Ali A, Li G, Jin B, Wang L, Xu Y (2023) In-vitro assessment of a novel plant rhizobacterium, Citrobacter freundii , for degrading and biocontrol of food mycotoxin deoxynivalenol

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X-ray photoelectron spectroscopy (XPS) was performed on a Thermo ESCALAB 250Xi spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) to investigate the elemental composition and chemical states of the samples