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Moek et al

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515,516 A preclinical study demonstrated that 3P10, a therapeutic antagonistic monoclonal antibody targeting GFRAL, can mitigate high-level lipid oxidation and prevent cancer cachexia in tumor-bearing mice by inhibiting RET signaling by blocking the GDF15-induced interaction between RET and GFRAL on the cell surface, even when the mice are under calorie-restricted conditions