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Supervision: Hartzell-Leggin, Newman, Whitmore, Arya, Brown, Hamm, Andy

E.CsiszarA.2mediated antioxidant response Am J Physiol.2011H363-H372

Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFB

* Correspondence: Jiawei Geng, [email protected]

Due to mitochondrial dysfunction and a lack of energy supply, cellular metabolism gradually shifts toward glycolysis, leading to lactate accumulation and further dopaminergic neuron damage [87]