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Gemcitabine induces cell-cycle arrest concomitant with caspase-3-mediated apoptosis [69]

Research Published studies

Melatonin can exert its antioxidant effects by either directly scavenging ROS and RNS or by indirectly up-regulating the expression and activities of endogenous antioxidants (Reiter et al., 2016)

Under pro-inflammatory conditions, M1 macrophages produce large amounts of ROS through glycolysis, which may lead to the depletion of NAD + and indirectly inhibit the enzymatic activity of SIRT1 and SIRT3 (141, 142)

Glutamate donates the nitrogen for the transamination step in serine biosynthesis, which can supply both glycine and cysteine for glutathione production