mitochondrial glutathione depletion

mitochondrial glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells Controlling glutathione entry into mitochondria:

Name: mitochondrial glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells Controlling glutathione entry into mitochondria:
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Controlling glutathione entry into mitochondria: potential roles for SLC25A39 in health and (treatment of) disease Signal Transduction and Targeted Therapy Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Cystinosis Pathophysiology Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes ScienceDirect Age related loss of mitochondrial glutathione exacerbates menadione induced inhibition of Complex I ScienceDirect

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the present inventors recognize that EDTA can be used as an inducer of C-terminal cleavage, given that it can chelate the Zn 2+ ions that suppress basal cleavage and release the POI ( FIG