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doi: 10.1016/j.ijbiomac.2020.12.005 140 KulkarniS

Liver and Spleen Weights Liver and spleen weights are expressed as a percentage of total body weight (for normal rats, liver, 3.24.0%

However, identity limitations, receptor pharmacology, phase 1 and phase 2 findings, phase 3 development, safety, pharmacokinetics, and analytical recommendations were reviewed in July 2026.

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Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified