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Description

Front Genet 8 , 100, (2017)

Current trends in the pharmacotherapy of cataracts

In patients, the ability to synthesize GSH in the lens decreases, and patients exhibit disrupted lens redox balance, reduced GSH concentrations, impaired GPX function, elevated iron redox levels, and increased lipid peroxidation, which indicates that age-related cataracts are closely related to ferroptosis (326, 327)