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131 While CD4 + T cells are mainly engaged in immune modulation, CD8 + CTLs are direct effector cells of proinflammatory factor production and tissue damage

Abbreviations GSH reduced Glutathione GSSG oxidized glutathione ROS Reactive Oxygen Species DUB deubiquitinase SGOC Serine-Glycine-One-Carbon ATF4 activating transcription factor 4 ncPRC1.1 non-canonical polycomb repressive complex 1.1 TNBCs Triple Negative Breast Cancers JmjC Jumonji C TMT Tandem Mass Tag ATAC-Seq Assay for Transposase-Accessible Chromatin sequencing ChIP chromatin immunoprecipitation TSS transcription start site Aass aminoadipate-semialdehyde synthase Nqo1 NAD(P)H quinone dehydrogenase 1 Prdx4 peroxiredoxin 4 Serpinb1b serpin family B member 1b PDH pyruvate dehydrogenase ATCase aspartate carbamoyltransferase 1C One-Carbon 3PG 3-phosphoglycerate SSP Serine Synthesis Pathway THF tetrahydrofolate EZH2 Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit TBHP tert-Butyl hydroperoxide PL Piperlongumine NAC N-Acetyl-Cysteine ER endoplasmic reticulum GLS glutaminase GCLC glutamate-cysteine ligase catalytic GCLM glutamate-cysteine ligase modifier GSS glutathione synthetase GSR glutathione reductase GPX4 glutathione peroxidase 4 GO Gene Ontology GSEA Gene set enrichment analysis ASNS asparagine synthetase BCAAs branched chain amino acids BCAT1/2 branched-chain aminotransferase 1/2 8-OH-Gua 8-hydroxyguanine SAM S-adenosyl-methionine SAH S-adenosylhomocysteine PHGDH Phosphoglycerate dehydrogenase 3-PHP 3-phosphohydroxypyruvate 3-PS 3-phosphoserine PSAT1 phosphoserine aminotransferase 1 PSPH phosphoserine phosphatase SHMT1/2 Serine hydroxymethyltransferase 1/2 MTHFD1/2 methylenetetrahydrofolate dehydrogenase 1/2 MTHFD1L methylenetetrahydrofolate dehydrogenase 1 like MTHFR 5,10-methyleneTHF reductase MTR methionine synthase CBS cystathionine -synthase CTH cystathionine -lyase/cystathionase ALDH1L1/2 Aldehyde Dehydrogenase 1 Family Member L1/2 OCR Oxygen Consumption Rate ISR integrated stress response PRC1/2 polycomb repressive complex 1/2 SEs super-enhancers KEGG Kyoto Encyclopedia of Genes and Genomes TCA tricarboxylic acid GLDC Glycine Decarboxylase Complex MTFMT Mitochondrial Methionyl-TRNA Formyl-transferase

10.1080/14756366.2016.1256882 188 PremjithR.KarthikeyanK

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