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Justin Laube, MD Medical Reviewer Justin Laube, MD, is a dual board-certified integrative and internal medicine physician, retreat leader, and healing educator with over 15 years of experience caring for patients w...

Pathogenic mechanisms associated with different clinical courses of multiple sclerosis

First, using germ-free animals, directional microbiota transplantation, and gene editing techniques to clarify the causal mechanisms by which protective genera such as Bifidobacterium regulate the hepcidin-FPN1 axis and key molecules of chondrocyte ferroptosis (GPX4, SLC7A11), thereby consolidating the logical chain of microbiota-iron metabolism-cell death. Second, leveraging longitudinal cohorts and multi-omics technologies to reveal the time-dependent evolution of the gut dysbiosis-iron overload-ferroptosis-intestinal dysfunction cycle and identify key windows for early intervention

Concurrently, EV-QuerCar elevated HES1 expression (Notch signaling) by 1.9-fold and 3.4-fold compared to NC and UV group, respectively (Fig

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