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Although erythropoiesis is enhanced, anemia likely continues due to elevated erythropoietin levels, which paradoxically heighten the vulnerability of RBCs to eryptosis

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Expression of peptides, toxic proteins, and proteins from a single reading frame Intein technology can be used to express challenging targets: small peptides can be expressed as part of properly folded proteins with affinity domains, toxic proteins can be expressed in an inactivated format, and proteins that function in an essential stoichiometry can be expressed from a single open reading frame

Originally containing the important cytosolic CXC motif, CD4 then underwent rapid evolution at two distinct protein-protein interaction sites in D1 and D2, both bearing important Cys residues

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