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196 In the tumor environment, succinate could be produced and released by tumor cells, and via interacting with succinate receptor 1 to activate phosphoinositide-3-kinase/protein kinase B pathway and upregulate HIF-1, inducing macrophage polarization, and enhancing tumor cell metastasis

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suppress appetite and increase energy expenditure

The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinsons disease

GSNO participates in the formation of the Cys93-nitrosated derivative of hemoglobin, S-nitrosohemoglobin (SNO-Hb), which has been suggested to play significant physiological role by acting as an endogenous NO donor and thus a regulator of blood pressure