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Periodontal EDS (pEDS) is characterized by severe and intractable periodontitis of early onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria Cardiac-valvular EDS (cvEDS) is characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising), and joint hypermobility (generalized or restricted to small joints)

Quick Answer: GLP-1 receptor agonists do not directly cause increased urination, as they are not diuretics and polyuria is not a recognised adverse effect

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Research history of metal ions in neurodegenerative diseases As early as 1924, iron deposition was first observed in the globus pallidus (GP) of PD patients through Perls and Turnbull staining (Fig