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A prior study displayed that mitochondria-derived vesicles (MDVs) were indispensable in OB differentiation and that Opa1 knockdown or Fis1 overexpression in OBs enhanced mitochondrial fragmentation and favoured MDV formation, increasing mitochondrial secretion and accelerating OB generation (163)

3.2 Core antioxidant enzymes were reprogrammed in a stage- and cultivar-dependent manner We first profiled genes encoding the core antioxidant enzymes that constitute the primary defense against ROS SOD s, CAT s and GPX s ( Figure 2 , Supplementary Figure S2 )

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This ensures not just short-term brightening, but sustained antioxidant protection and long-term skin health

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