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Characterization of more selective central nervous system Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

49 In another phase 1 study conducted in 37 Japanese patients, the most common treatment-related side effects were nausea, vomiting, abdominal discomfort, diarrhea, and headache, mostly mild to moderate in severity

DAO, or diamine oxidase, is an enzyme produced by healthy gut cells that breaks down histamine in the small intestine

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Moreover, such endogenous brain proteins, cross-seeded to induce aggregation into toxic oligomers, could become the pernicious species responsible for growth of slowly expanding lesions in progressive MS, or form tiny islands of deposited seed to which microglia react to form nodules in pre-lesions