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For example, when a respiratory viral infection is combined with invasive fungal disease, cytokines attract more immune cells, which in turn produce more cytokines, creating an inflammatory cycle that damages lung tissues and causes the formation of fibrin and scar tissue, which allows fluids to seep into and fill the lung cavities, leading to respiratory failure (66)

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BAX, Bcl-2-associated X protein

Interestingly, WDR11 is also required for primordial germ cell (PGC) development and regulates both canonical and noncanonical Hedgehog (HH) signaling 49

doi: 10.2337/db08-0604 101 XuLSpinasGANiessenM