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Six controlled trials in approximately 900 participants are summarized in Stier et al

They are simply anti-inflammatories

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DOI: 10.1111/acel.14083 Circulation Research (2018) Ahajournals.org Reviewed the roles of SIRT1, SIRT3, SIRT4, SIRT6, SIRT7, and NAD+ across cardiovascular ageing, confirming protective roles against dyslipidaemia, obesity, type 2 diabetes, arrhythmia, cardiac fibrosis, hypertrophy, and ischaemia-reperfusion injury

It is worth noting that the above response does not depend on type 1 interferon or inflammatory pathway