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The reaction is particular for thiol groups and characterized by fast kinetics, making it suitable for measuring thiol concentrations in various biological systems

However, sample sizes were modest, and long-term safety and efficacy data remain absent from peer-reviewed literature

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PAs beneficial effects might be attributed to iron chelation, decreased CYP2E1 mRNA expression, increased SIRT -1 expression at both mRNA and protein levels, and decreasing oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] [70].Dayal S, Brown KL, Weydert CJ, Oberley LW, Arning E, Bottiglieri T, Faraci FM, Lentz SR, Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction