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Pharmacodynamic studies comparing administration routes showed that oral delivery of crocodilian oil reached peak anti-inflammatory activity at 3 h (60.8% 5.5%), whereas topical application peaked at 12 h (57.9% 5.9%) (14)

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All experimental procedures were approved by the Ethics Committee of the Army Medical University (Approval No

Although some clinical trials are in progress, due to severe side effects such as those caused by an undesired pharmacological activity, suppression of the innate immune response to viral and bacterial infections, and damage to the central nervous system and liver, 244,245 these drugs remain challenging for a clinical application