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This leads to increased cyclinD1 expression, which promotes cell growth and cycle progression [45,46,47]

The low cytotoxicity of APE suggests that the extract exerts its protective effects without compromising cellular integrity, a critical consideration for potential pharmacological applications

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(2001) Characterization of biotransformation enzyme activities in primary rat proximal tubular cells Chemico-Biol., Interact., 134, 167-190 20

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