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However, only a small percentage of patients ( 1%) achieve the desired endpoint of functional cure, defined as the loss of hepatitis B surface antigen (HBsAg) and HBV DNA below the level of quantitation, that permits safe discontinuation of therapy [4, 5]

[11] [12] [13] [14] [15] [16] In obesity, a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes), resulting in an inability to detect satiety despite high energy stores and high levels of leptin

The role of inflammation in HPV infection of the oesophagus

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