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We investigated their effects on cell proliferation by WST-8, apoptosis by Caspase-3/7 activity, sphere formation, and tumour formation as well as signalling pathways regulating these phenotypes

Nevertheless, the trial-specific modified device demonstrated insufficient reliability in a clinical study, necessitating its mid-trial replacement with the Precision Olfactory Delivery (POD) device (Impel Pharmaceuticals, Seattle, WA) [67]