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The net result of AOD9604 action is preferential reduction of adipose tissue mass, particularly visceral and subcutaneous fat depots, without the hyperglycemic, insulin-desensitizing, or growth-promoting effects of full-length growth hormone

Aberrant K63-linked ubiquitination disrupts intracellular signaling networks and autophagic flux, contributing to the accumulation of toxic protein species and impaired stress responses

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This approach allowed us to explore the functions of key genes and the mechanisms of co-morbidity associated with the disease

PPP involves the formation of a bypass from glucose-6-phosphate, an intermediate product of glycolysis, which produces fructose-6-phosphate and glyceraldehyde-3-phosphate through two stages of oxidation and group transfer back to glycolysis, also referred to as the hexose monophosphate shunt