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Prx3, which is found in mitochondria, is downregulated in cells expressing SOD1 G37R and SOD1 G93A mutants, and in SOD1 G93A transgenic mice (Wood-Allum et al., 2006)

When applied to the skin, it is incorporated into the inner layers and offers antioxidant protection against the harmful UV radiation of the sun, and a randomized, placebo-controlled, double-blind study in 33 women (mean age 54.4 years) demonstrated that 12 weeks of treatment with a cream containing 5% ALA improved photoaging-related clinical features of facial skin

Shpakov A, Chistyakova O, Derkach K, Bondareva V

*Redox Biology*, 10, 274-284

Brain Pathol (Zurich, Switzerland)