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[28] Metal ion binding [edit] Beyond the iron-sulfur proteins, many other metal cofactors in enzymes are bound to the thiolate substituent of cysteinyl residues

Importantly, miR-20a-5p inhibits ACSL4-dependent ferroptosis by targeting the 3UTR of ACSL4 mRNA as a negative regulator of ACSL4

doi: 10.1539/joh.N8001

POP patients exhibit increased levels of inflammatory cytokines (IL-1, TNF, IFN, and others) in the front vaginal wall, which may alter collagen metabolism and contribute to POP