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The body has limits to how quickly it can mobilize and process stored fat

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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

Specifically, investigations on the Chinese Han population identified the rs10891644 variant as significantly associated with obesity susceptibility, with heterozygous individuals (GT type) exhibiting heightened vulnerability (Zhou et al., 2017)